lipoxygenases
Sign in to saveLipoxygenases () (LOX) are a family of (non-heme) iron-containing enzymes, more specifically oxidative enzymes, most of which catalyze the dioxygenation of polyunsaturated fatty acids in lipids containing a cis,cis-1,4-pentadiene into cell signaling agents that serve diverse roles as autocrine signals that regulate the function of their parent cells, paracrine signals that regulate the function of nearby cells, and endocrine signals that regulate the function of distant cells.
Key facts
- Protein family.Symbol
- Lipoxygenase
- Protein family.Name
- Lipoxygenase
- Protein family.image
- 2p0m.png
- Protein family.width
- 220
- Protein family.caption
- Structure of rabbit reticulocyte 15S-lipoxygenase
- Protein family.Pfam
- PF00305
- Protein family.InterPro
- IPR013819
- Protein family.PROSITE
- PDOC00077
- Protein family.SCOP
- 2sbl
- Protein family.OPM family
- 80
- Protein family.OPM protein
- 2p0m
via Wikipedia infobox
Article
10 sectionsContents
- Biochemistry
- Biological function and classification
- Plant lipoxygenases
- Human lipoxygenases
- Mouse lipoxygenases
- 3D structure
- Active site
- Biochemical classification
- References
- External links
Lipoxygenases () (LOX) are a family of (non-heme) iron-containing enzymes, more specifically oxidative enzymes, most of which catalyze the dioxygenation of polyunsaturated fatty acids in lipids containing a cis,cis-1,4-pentadiene into cell signaling agents that serve diverse roles as autocrine signals that regulate the function of their parent cells, paracrine signals that regulate the function of nearby cells, and endocrine signals that regulate the function of distant cells.
The lipoxygenases are related to each other based upon their similar genetic structure and dioxygenation activity. However, one lipoxygenase, ALOXE3, while having a lipoxygenase genetic structure, possesses relatively little dioxygenation activity; rather its primary activity appears to be as an isomerase that catalyzes the conversion of hydroperoxy unsaturated fatty acids to their 1,5-epoxide, hydroxyl derivatives.