🌐EnglishEnglishDeutschItalianoNederlandsPortuguês日本語ProteinQ409970· pop 11· linked from 82 articlestryptophan 2,3-dioxygenaseAlso known as TO, tryptophan pyrrolase, tryptophan oxygenase, TDO2, tryptophanase, tryptamin 2,3-dioxygenase, TRPOmammalian protein found in Homo sapiensResearch4,624 papersTryptophan 2,3-dioxygenase-positive matrix fibroblasts fuel breast cancer lung metastasis via kynurenine-mediated ferroptosis resistance of metastatic cells and T cell dysfunction.Cancer communications (London, England) · 2024Indoleamine 2,3-dioxygenase (IDO) inhibitors and cancer immunotherapy.Cancer treatment reviews · 2022Editorial: Targeting Indoleamine 2,3-dioxygenases and Tryptophan Dioxygenase for Cancer Immunotherapy.Frontiers in immunology · 2021Tryptophan 2,3-dioxygenase: a review of the roles of the heme and copper cofactors in catalysis.Bioinorganic chemistry · 1975Inhibitory effect of ascorbate on tryptophan 2,3-dioxygenase.Journal of biochemistry · 2022via PubMedAvailable in 10 languagesDeutsch日本語PortuguêsItalianoSerbianSerbian (Latin)SlovakTatarUkrainianvia Wikidata sitelinks · CC0ConnectionsenzymeEntityQ180686EntityCategoriesEC 1.13.11Enzymes of known structureGenes on human chromosome 4Heme enzymes