Category

Helicases

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thumb|upright=1.2|Structure of Escherichia coli|E. coli helicase RuvA (note that the helicase core in RuvAB complex is RuvB and not RuvA and that RuvA alone do not show helicase activity) Helicases are a class of enzymes that are vital to all organisms. Their main function is to unpack an organism's genetic material. Helicases are motor proteins that move directionally along a nucleic double helix, separating the two hybridized nucleic acid strands (hence helic- + -ase), via the energy gained from ATP hydrolysis. There are many helicases, representing the great variety of processes in which st

prokaryotic protein

DExD/H-box helicase 58

RIG-I (retinoic acid-inducible gene I) is a cytosolic pattern recognition receptor (PRR) that can mediate induction of a type-I interferon (IFN1) response. RIG-I is an essential molecule in the innate immune system for recognizing cells that have been infected with a virus. These viruses can include West Nile virus, Japanese Encephalitis virus, influenza A, Sendai virus, flavivirus, and coronaviruses.

protein-coding gene in the species Homo sapiens

Helicase-dependent amplification

isothermic nucleic acid amplification test technology

ERCC excision repair 3, TFIIH core complex helicase subunit

XPB (xeroderma pigmentosum type B) is an ATP-dependent DNA helicase in humans that is a part of the TFIIH transcription factor complex.

DNA helicase, DnaB type

InterPro Family

ERCC excision repair 2, TFIIH core complex helicase subunit

TFIIH subunit XPD is a protein that in humans is encoded by the ERCC2 (ERCC excision repair 2) gene. It is a component of the general transcription and DNA repair factor IIH (TFIIH) core complex involved in transcription-coupled nucleotide excision repair.

eukaryotic translation initiation factor

BLM RecQ like helicase

mammalian protein found in Homo sapiens

protein-coding gene in the species Homo sapiens

class of enzymes

BRCA1 interacting protein C-terminal helicase 1

Fanconi anemia group J protein (FANCJ) is a protein that in humans is encoded by the BRCA1-interacting protein 1 (BRIP1) gene. The protein is a 5'-3' DNA helicase (EC: 5.2.6.3) and ATPase that repairs interstrand crosslinks (ICLs), double-stranded breaks (DSBs) and guanine quadruplexes (G4) through the Fanconi anemia (FA) pathway. Damage or depletion of BRIP1 has been associated with various cancers as well as Fanconi anemia.