helicase
Sign in to savethumb|upright=1.2|Structure of Escherichia coli|E. coli helicase RuvA (note that the helicase core in RuvAB complex is RuvB and not RuvA and that RuvA alone do not show helicase activity) Helicases are a class of enzymes that are vital to all organisms. Their main function is to unpack an organism's genetic material. Helicases are motor proteins that move directionally along a nucleic double helix, separating the two hybridized nucleic acid strands (hence helic- + -ase), via the energy gained from ATP hydrolysis. There are many helicases, representing the great variety of processes in which st
Article
17 sectionsContents
- Function
- Activation barrier in helicase activity
- Active and passive helicases
- History of DNA helicases
- Structural features
- Superfamilies
- Helicase disorders and diseases
- ATRX helicase mutations
- XPD helicase point mutations
- RecQ family mutations
- RNA helicases
- Diagnostic tools for helicase measurement
- Measuring and monitoring helicase activity
- Determining helicase polarity
- See also
- References
- External links
thumb|upright=1.2|Structure of Escherichia coli|E. coli helicase RuvA (note that the helicase core in RuvAB complex is RuvB and not RuvA and that RuvA alone do not show helicase activity) Helicases are a class of enzymes that are vital to all organisms. Their main function is to unpack an organism's genetic material. Helicases are motor proteins that move directionally along a nucleic double helix, separating the two hybridized nucleic acid strands (hence helic- + -ase), via the energy gained from ATP hydrolysis. There are many helicases, representing the great variety of processes in which strand separation must be catalyzed. Approximately 1% of eukaryotic genes code for helicases.
The human genome codes for 95 non-redundant helicases: 64 RNA helicases and 31 DNA helicases. Many cellular processes, such as DNA replication, transcription, translation, recombination, DNA repair and ribosome biogenesis involve the separation of nucleic acid strands that necessitates the use of helicases. Some specialized helicases are also involved in sensing viral nucleic acids during infection and fulfill an immunological function. Genetic mutations that affect helicases can have wide-reaching impacts for an organism, due to their significance in many biological processes.