Hydrolase inhibitors

Cilastatin inhibits the human enzyme dehydropeptidase.

chemical compound

Thapsigargin is a non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA). Structurally, thapsigargin is classified as a guaianolide, and is extracted from a plant, Thapsia garganica. It is a tumor promoter in mammalian cells.

chemical compound

Migalastat, sold under the brand name Galafold, is a medication used for the treatment of Fabry disease, a rare genetic disorder. Migalastat is an alpha-galactosidase A (alpha-Gal A) pharmacological chaperone. It was developed by Amicus Therapeutics.

Lipstatin is a potent, irreversible inhibitor of pancreatic lipase. It is a natural product that was first isolated from the actinobacterium Streptomyces toxytricini.

RHC80267 is an inhibitor of diacylglycerol lipase. Diacylglycerol lipase generates the endocannabinoid 2-arachidonoylglycerol from diacylglycerol.

chemicals which prevent breakdown of acetylcholine and butyrylcholine

Serine proteinase inhibitors which inhibit trypsin. They may be endogenous or exogenous compounds

Sivelestat (INN, research name ONO 5046, marketed as Elaspol) is an inhibitor of human neutrophil elastase.

Talopeptin is a chemical compound derived from cultures of Streptomyces. It is a known reversible inhibitor of thermolysin and is expected to inhibit other metalloproteinases. Chemically, talopeptin differs from its closely related peptidase inhibitor phosphoramidon by a single stereocenter.

Phosphoramidon is a chemical compound derived from cultures of Streptomyces tanashiensis. It is an inhibitor of the enzyme thermolysin, of the membrane metallo-endopeptidase, and of the endothelin converting enzyme. Chemically, phosphoramidon differs from its closely related peptidase inhibitor talopeptin by a single stereocenter.