sivelestat
Sign in to saveAlso known as Elaspol®, LY544349, ONO-5046, Ono-EI-600
Sivelestat (INN, research name ONO 5046, marketed as Elaspol) is an inhibitor of human neutrophil elastase.
Research
555 papers- Sivelestat ameliorates sepsis-induced myocardial dysfunction by activating the PI3K/AKT/mTOR signaling pathway.International immunopharmacology · 2024
- Sivelestat Sodium Alleviates Ischemia-Reperfusion-Induced Acute Kidney Injury via Suppressing TLR4/Myd88/NF-κB Signaling Pathway in Mice.Drug design, development and therapy · 2024
- Clinical Utility of the Sivelestat for the Treatment of ALI/ARDS: Moving on in the Controversy?Intensive care research · 2023
- Sivelestat for septic patients with acute respiratory distress syndrome: a systematic review and meta-analysis of a deadly duo.Frontiers in medicine · 2025
- Sivelestat-Loaded Neutrophil-Membrane-Coated Antioxidative Nanoparticles for Targeted Endothelial Protection in Sepsis.Pharmaceutics · 2025
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 434.114772
- Has use
- medication
Show 3 more facts
- chemical formula
- C₂₀H₂₂N₂O₇S
- canonical SMILES
- CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)O
- Commons category
- Sivelestat
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
2 sectionsContents
- Synthesis
- References
{{Infobox drug | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 464392270 | IUPAC_name = N-{2-[({4-[(2,2-dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycine | image = Sivelestat.svg | image_class = skin-invert-image
| tradename = | Drugs.com = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = Not approved | legal_status = Rx-only | routes_of_administration = IV
Excerpted from Wikipedia’s “sivelestat” article, available under the CC BY-SA 4.0 licence.