PET radiotracers

200px|thumbnail|right| A carbon-11 labelled radiopharmaceuticalRadiopharmaceuticals, or medicinal radiocompounds, are a group of pharmaceutical drugs containing radioactive isotopes. Radiopharmaceuticals can be used as diagnostic and therapeutic agents. Radiopharmaceuticals emit radiation themselves, which is different from contrast media which absorb or alter external electromagnetism or ultrasound. Radiopharmacology is the branch of pharmacology that specializes in these agents.

pharmaceutical drug

2,5-Dimethoxy-4-iodoamphetamine (DOI) is a psychedelic drug of the phenethylamine, amphetamine, and DOx families. It is little-used recreationally, but is widely used in scientific research in the study of psychedelics and serotonin receptors. The drug is taken orally.

chemical compound

chemical compound

chemical compound

Copper-64 (Cu) is a positron and beta emitting isotope of copper (exhibiting both forms of beta decay), with applications in molecular radiotherapy and positron emission tomography. Its unusually long half-life (12.7 hours) for a positron-emitting isotope makes it increasingly useful when attached to various ligands for PET and PET-CT scanning.

chemical compound

Rubidium-82 (82Rb) is a radioactive isotope of rubidium. 82Rb is widely used in myocardial perfusion imaging. This isotope undergoes rapid uptake by myocardiocytes, which makes it a valuable tool for identifying myocardial ischemia in Positron Emission Tomography (PET) imaging. 82Rb is used in the pharmaceutical industry and is marketed as rubidium-82 chloride under the trade names RUBY-FILL and CardioGen-82.

Raclopride is a typical antipsychotic. It acts as a selective antagonist on D2 dopamine receptors. It has been used in trials studying Parkinson Disease.

25B-NBOMe, also known as NBOMe-2C-B, Cimbi-36, or as '''N-(2-methoxybenzyl)-4-bromo-2,5-dimethoxyphenethylamine', is a psychedelic drug of the phenethylamine, 2C, and 25-NB (NBOMe) families. It is the N''-(2-methoxybenzyl) derivative of 2C-B. The drug is taken sublingually, bucally, or intranasally.

Setoperone (; ; developmental code name R-52245) is a compound that is a ligand to the 5-HT2A receptor. It can be radiolabeled with the radioisotope fluorine-18 and used as a radioligand with positron emission tomography (PET). Several research studies have used the radiolabeled setoperone in neuroimaging for the studying neuropsychiatric disorders, such as depression or schizophrenia. The drug was first described by at least 1984.

AM-694 (1-(5-fluoropentyl)-3-(2-iodobenzoyl)indole) is a designer drug that acts as a potent and selective agonist for the cannabinoid receptor CB1. It is used in scientific research for mapping the distribution of CB1 receptors.