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AM-694
Sign in to saveAM-694 (1-(5-fluoropentyl)-3-(2-iodobenzoyl)indole) is a designer drug that acts as a potent and selective agonist for the cannabinoid receptor CB1. It is used in scientific research for mapping the distribution of CB1 receptors.
In the Vinony graph
Vinony's link graph records 452 inbound references to AM-694, and connects out to JWH-210, synhexyl and digital object identifier.
Vinony files it under 2-Iodophenyl compounds, AM cannabinoids and Benzoylindoles.
Vinony links it to 5 Wikipedia language editions.
Chemical data
- Formula
- C20H19FINO
- Molecular weight
- 435.3 g/mol
- IUPAC name
- [1-(5-fluoropentyl)indol-3-yl]-(2-iodophenyl)methanone
- SMILES
- C1=CC=C2C(=C1)C(=CN2CCCCCF)C(=O)C3=CC=CC=C3I
- InChIKey
- LFFIIZFINPPEMC-UHFFFAOYSA-N
- XLogP
- 5.3
- Polar surface area
- 22 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 435.05
Show 2 more facts
- canonical SMILES
- C1=CC=C2C(=C1)C(=CN2CCCCCF)C(=O)C3=CC=CC=C3I
- chemical formula
- C₂₀H₁₉FINO
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
6 sectionsContents
- Pharmacology
- Metabolism
- Legal status
- Finland
- See also
- References
AM-694 (1-(5-fluoropentyl)-3-(2-iodobenzoyl)indole) is a designer drug that acts as a potent and selective agonist for the cannabinoid receptor CB1. It is used in scientific research for mapping the distribution of CB1 receptors.
==Pharmacology== AM-694 is an agonist for cannabinoid receptors. It has a Ki of 0.08 nM at CB1 and 18 times selectivity over CB2 with a Ki of 1.44 nM. It is unclear what is responsible for this unusually high CB1 binding affinity, but it makes the 18F radiolabelled derivative of AM-694 useful for mapping the distribution of CB1 receptors in the body.
Excerpted from Wikipedia’s “AM-694” article, available under the CC BY-SA 4.0 licence.