1-hydroxybenzotriazole
Hydroxybenzotriazole (abbreviated HOBt) is an organic compound with the formula . It is a derivative of benzotriazole. It is a white crystalline powder, which as a commercial product contains some water (~11.7% wt as the HOBt monohydrate crystal). Anhydrous HOBt is explosive. It is mainly used to suppress the racemization and to improve the efficiency of peptide synthesis.
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3 sectionsContents
- Use in peptide synthesis
- Safety
- References
Hydroxybenzotriazole (abbreviated HOBt) is an organic compound with the formula . It is a derivative of benzotriazole. It is a white crystalline powder, which as a commercial product contains some water (~11.7% wt as the HOBt monohydrate crystal). Anhydrous HOBt is explosive. It is mainly used to suppress the racemization and to improve the efficiency of peptide synthesis.
==Use in peptide synthesis== center|500x500px Automated peptide synthesis involves the condensation of the amino group of protected amino acids with the activated ester. HOBt is used to produce such activated esters which react with amines at ambient temperature to give amides.
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BenzotriazolesBiochemistryBiochemistry methodsChembox having GHS dataChembox image size setChemical articles with multiple CAS registry numbersChemical articles with multiple compound IDsChemical articles with multiple PubChem CIDsChemicals using indexlabelsECHA InfoCard ID from WikidataHydroxylaminesPeptide coupling reagents