17β-estradiol
Sign in to saveEstradiol (E2), also called oestrogen, oestradiol, is an estrogen steroid hormone and the major female sex hormone. It is involved in the regulation of female reproductive cycles such as estrous and menstrual cycles. Estradiol is responsible for the development of female secondary sexual characteristics such as the breasts, widening of the hips and a female pattern of fat distribution. It is also important in the development and maintenance of female reproductive tissues such as the mammary glands, uterus and vagina during puberty, adulthood and pregnancy. It also has important effects in many
AI overview
17β-estradiol is the main female sex hormone in the body, responsible for regulating reproductive cycles and developing female characteristics like breast growth and hip widening. It plays a crucial role in maintaining the health and function of female reproductive tissues throughout puberty, adulthood, and pregnancy, and has important effects on many other body systems.
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Research
140,446 papers- 17β-Estradiol Ameliorates Postoperative Cognitive Dysfunction in Aged Mice via miR-138-5p/SIRT1/HMGB1 Pathway.The international journal of neuropsychopharmacology · 2024
- Dihydrotestosterone and 17β-estradiol modulate TMJ osteoarthritis development and reveal sex-specific differences in pathogenesis.Scientific reports · 2025
- Oestrogenic Regulation of Mitochondrial Dynamics.International journal of molecular sciences · 2022
- From mitochondria to sarcopenia: role of 17β-estradiol and testosterone.Frontiers in endocrinology · 2023
- Actions of 17β-estradiol and testosterone in the mitochondria and their implications in aging.Ageing research reviews · 2013
via PubMed
Article
27 sectionsContents
- Biological function
- Sexual development
- Reproduction
- Female reproductive system
- Male reproductive system
- Skeletal system
- Skin health
- Nervous system
- Gynecological cancers
- Cardiovascular system
- Other functions
- Biological activity
- Biochemistry
- Biosynthesis
- Distribution
- Metabolism
- Excretion
- Levels
- Measurement
- Ranges
- Medical use
- Chemistry
- Neuropsychopharmacology
- History
- Society and culture
- Etymology
- References
Estradiol (E2), also called oestrogen, oestradiol, is an estrogen steroid hormone and the major female sex hormone. It is involved in the regulation of female reproductive cycles such as estrous and menstrual cycles. Estradiol is responsible for the development of female secondary sexual characteristics such as the breasts, widening of the hips and a female pattern of fat distribution. It is also important in the development and maintenance of female reproductive tissues such as the mammary glands, uterus and vagina during puberty, adulthood and pregnancy. It also has important effects in many other tissues including bone, fat, skin, liver, and the brain.
Though estradiol levels in males are much lower than in females, estradiol has important roles in males as well. Apart from humans and other mammals, estradiol is also found in most vertebrates and crustaceans, insects, fish, and other animal species.