2,4-dinitrochlorobenzene

Also known as 1-Chloro-2,4-dinitrobenzene, DNCB, Cdnb, Chlorodinitrobenzene, 6-Chloro-1,3-dinitrobenzene, 4-Chloro-1,3-dinitrobenzene, 2,4-Dinitrophenyl chloride

2,4-Dinitrochlorobenzene (DNCB) is an organic compound with the chemical formula (O2N)2C6H3Cl. It is a yellow solid that is soluble in organic solvents. It is an intermediate for the industrial production of other compounds.

Research

3,457 papers

TRPA1 Mediates Contact Hypersensitivity Induced by 2,4-Dinitrochlorobenzene.The Journal of investigative dermatology · 2023
Inhibitory Effect of Centella asiatica Extract on DNCB-Induced Atopic Dermatitis in HaCaT Cells and BALB/c Mice.Nutrients · 2020
Vasicine alleviates 2,4-dinitrochlorobenzene-induced atopic dermatitis and passive cutaneous anaphylaxis in BALB/c mice.Clinical immunology (Orlando, Fla.) · 2022
Polynucleotides Enhance Skin Barrier Function and Reduce Inflammation in a 2,4-Dinitrochlorobenzene-Induced Mouse Model of Atopic Dermatitis.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2025
Protective Effect of Camellia japonica Extract on 2,4-Dinitrochlorobenzene (DNCB)-Induced Atopic Dermatitis in an SKH-1 Mouse Model.International journal of molecular sciences · 2025

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Encyclopedic overview

3 sections

Contents

Preparation and reactions
Safety
References

==Preparation and reactions== DNCB is produced commercially by the nitration of p-nitrochlorobenzene with a mixture of nitric and sulfuric acids. Other methods afford the compound less efficiently include the chlorination of 1,3-dinitrobenzene, nitration of o-nitrochlorobenzene and the dinitration of chlorobenzene.

Excerpted from Wikipedia’s “2,4-dinitrochlorobenzene” article, available under the CC BY-SA 4.0 licence.