1-fluoro-2,4-dinitrobenzene
Also known as Sanger's reagent, dinitrofluorobenzene, DNFB, 2,4-dinitro-1-fluorobenzene
1-Fluoro-2,4-dinitrobenzene (commonly called '''Sanger's reagent, dinitrofluorobenzene, DNFB or FDNB''') is a chemical that reacts with the N-terminal amino acid of polypeptides. This can be helpful for sequencing proteins.
Research
2,324 papers- 1-Fluoro-2,4-dinitrobenzene and its derivatives act as secretagogues on rodent mast cells.European journal of immunology · 2017
- 1:2:4-Fluorodinitrobenzene.The Biochemical journal · 1947
- Dimethylglycine, a Methionine Metabolite, Participates in the Suppressive Effect of Methionine on 1-Fluoro-2,4-dinitrobenzene-Induced Dermatitis.Biological & pharmaceutical bulletin · 2023
- Spectrophotometric determination of lisinopril in tablets using 1-fluoro-2,4-dinitrobenzene reagent.Journal of pharmaceutical and biomedical analysis · 2002
- L-lactate-2-monooxygenase. Sequence of peptides containing residues modified by 1-fluoro-2,4-dinitrobenzene.The Journal of biological chemistry · 1987
via PubMed
Article
6 sectionsContents
- Preparation
- Uses
- See also
- References
- Literature
- External links
1-Fluoro-2,4-dinitrobenzene (commonly called '''Sanger's reagent, dinitrofluorobenzene, DNFB or FDNB''') is a chemical that reacts with the N-terminal amino acid of polypeptides. This can be helpful for sequencing proteins.
== Preparation == In 1936, Gottlieb presented a synthesis in which 1-chloro-2,4-dinitrobenzene reacted with potassium fluoride (KF) in nitrobenzene: 450px|Synthesis of 1-fluoro-2,4-dinitrobenzene from 1-chloro-2,4-dinitrobenzene in nitrobenzene with potassium fluoride