4-hydroxy-TEMPO
Sign in to save4-Hydroxy-TEMPO or TEMPOL, formally 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl, is a heterocyclic compound. Like the related TEMPO, it is used as a catalyst and chemical oxidant by virtue of being a stable aminoxyl radical. Its major appeal over TEMPO is that it is less expensive, being produced from triacetone amine, which is itself made via the condensation of acetone and ammonia. This makes it economically viable on an industrial scale.
Chemical data
- Formula
- C9H18NO2
- Molecular weight
- 172.24 g/mol
via PubChem
Research
142 papers- Nitroxide Hormesis in Yeast: 4-Hydroxy-TEMPO Modulates Aging, and Cell Cycle.Molecules (Basel, Switzerland) · 2026
- 4-Hydroxy TEMPO attenuates dichlorvos induced microglial activation and apoptosis.ACS chemical neuroscience · 2014
- Tempol (4-hydroxy tempo) protects mice from cisplatin-induced acute kidney injury via modulation of expression of aquaporins and kidney injury molecule-1.Drug and chemical toxicology · 2022
- Fluorescence quenching of fluoroquinolone antibiotics by 4-hydroxy-TEMPO in aqueous solution.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy · 2014
- 4-hydroxy tempo improves mitochondrial and neurobehavioral deficits in experimental model of Huntington's disease.Synapse (New York, N.Y.) · 2015
via PubMed
Article
2 sectionsContents
- See also
- References
4-Hydroxy-TEMPO or TEMPOL, formally 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl, is a heterocyclic compound. Like the related TEMPO, it is used as a catalyst and chemical oxidant by virtue of being a stable aminoxyl radical. Its major appeal over TEMPO is that it is less expensive, being produced from triacetone amine, which is itself made via the condensation of acetone and ammonia. This makes it economically viable on an industrial scale.
thumb|center|350px|Example synthesis of 4-Hydroxy-TEMPO from phorone, which is itself made from acetone and ammonia