5-hydroxycytosine
Sign in to saveAlso known as hydroxycytosine
5-Hydroxycytosine is an oxidized form of cytosine that is associated with an increased frequency of C to T transition mutations, with some C to G transversions. It does not distort the DNA molecule and is readily bypassed by replicative DNA polymerases.
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 127.0381764
Show 2 more facts
- canonical SMILES
- C1=NC(=O)NC(=C1O)N
- chemical formula
- C₄H₅N₃O₂
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Encyclopedic overview
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5-Hydroxycytosine is an oxidized form of cytosine that is associated with an increased frequency of C to T transition mutations, with some C to G transversions. It does not distort the DNA molecule and is readily bypassed by replicative DNA polymerases.
It has been shown in vitro to miscode for adenine.
Excerpted from Wikipedia’s “5-hydroxycytosine” article, available under the CC BY-SA 4.0 licence.