Structure via PubChem · Public domain (PubChem)
6-methoxyguanine
Sign in to saveAlso known as 2-Amino-6-methoxypurine, 6-Methoxy-1H-purine-2-amine, O(6)-methylguanine, O-(6)-Methylguanine
'6-O-Methylguanine' is a derivative of the nucleobase guanine in which a methyl group is attached to the oxygen atom. It base-pairs to thymine rather than cytosine, causing a G:C to A:T transition in DNA.
Chemical data
- Formula
- C6H7N5O
- Molecular weight
- 165.15 g/mol
- IUPAC name
- 6-methoxy-7H-purin-2-amine
- SMILES
- COC1=NC(=NC2=C1NC=N2)N
- InChIKey
- BXJHWYVXLGLDMZ-UHFFFAOYSA-N
- XLogP
- -0.2
- Polar surface area
- 89.7 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Mass
- 165.065
Show 2 more facts
- chemical formula
- C₆H₇N₅O
- canonical SMILES
- COC1=NC(=NC2=C1NC=N2)N
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
6 sectionsContents
- Formation
- Repair and carcinogenicity
- Mutagenicity
- Other effects
- See also
- References
'6-O-Methylguanine' is a derivative of the nucleobase guanine in which a methyl group is attached to the oxygen atom. It base-pairs to thymine rather than cytosine, causing a G:C to A:T transition in DNA.
== Formation ==
Excerpted from Wikipedia’s “6-methoxyguanine” article, available under the CC BY-SA 4.0 licence.