Research
142,941 papers- DNA repair defects in cancer and therapeutic opportunities.Genes & development · 2022
- Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints.Annual review of biochemistry · 2004
- Prime Editing: Mechanistic Insights and DNA Repair Modulation.Cells · 2025
- Transcription-Coupled Nucleotide Excision Repair and the Transcriptional Response to UV-Induced DNA Damage.Annual review of biochemistry · 2023
- RNA in DNA repair.DNA repair · 2020
via PubMed
Article
DNA damage resulting in multiple broken chromosomes
DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. A weakened capacity for DNA repair is a risk factor for the development of cancer. DNA is constantly modified in cells, by internal metabolic by-products, and by external ionizing radiation, ultraviolet light, and medicines, resulting in spontaneous DNA damage involving tens of thousands of individual molecular lesions per cell per day. DNA modifications can also be programmed.