Acantólisis
Sign in to saveAcantholysis is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes, seen in diseases such as pemphigus vulgaris, Grover’s disease, and Hailey-Hailey Disease. It is absent in bullous pemphigoid, making it useful for differential diagnosis. This disruption between cells causes intra-epidermal clefts, vesicles and bullae due to cells becoming rounded and no longer attached to one another.
Key facts
- Medical condition.name
- Acantholysis
- Medical condition.image
- Diseases of Swine 25-5.png
- Medical condition.caption
- Foot-and-mouth disease - acantholysis in a sample of a skin vesicle: Necrosis of the stratum spinosum can be observed, and keratinocytes floating in the vesicular fluid (spongiosa).
- Medical condition.field
- Dermatology
via Wikipedia infobox
Research
1,787 papers- [Acantholysis].Annales de dermatologie et de venereologie · 2017
- Pemphigus, a pathomechanism of acantholysis.The Australasian journal of dermatology · 2017
- Incidental acantholysis.Journal of cutaneous pathology · 1993
- What protein kinases are crucial for acantholysis and blister formation in pemphigus vulgaris? A systematic review.Journal of cellular physiology · 2022
- Unilateral nipple erosion with acantholysis.International journal of dermatology · 2019
via PubMed
Wikidata facts
- Subclass of
- skin disease
Show 3 more facts
- health specialty
- dermatology
- exact match
- purl.obolibrary.org/obo/HP_0100792
- Commons category
- Acantholysis
Sources (3)
via Wikidata · CC0
Article · Español
Se denomina acantólisis (del griego lysis, disolución) a la interrupción de las conexiones intercelulares entre queratinocitos de la epidermis, causada por lisis de la sustancia cemento intercelular (Desmogleína), con interrupción secundaria de los desmosomas y a menudo formación de una secuencia definida de elementos degenerativos celulares; se asocia a la formación de vesículas epidérmicas en condiciones tales como el pénfigo vulgar, pénfigo foliáceo y otras alteraciones de la piel.
Abstract from DBpedia / Wikipedia · CC BY-SA