AKR1C3
Sign in to saveAlso known as DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS
Aldo-keto reductase family 1 member C3 (AKR1C3), also known as 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5, HSD17B5) or 3α-hydroxysteroid dehydrogenase type 2 (3α-HSD2) is a steroidogenic enzyme that in humans is encoded by the AKR1C3 gene.
Gene data
AKR1C3- Name
- aldo-keto reductase family 1 member C3
- Type
- protein-coding
- Position
- 5,035,354–5,108,244 (+)
- Aliases
- DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS
- Ensembl
- ENSG00000196139
- RefSeq RNA
- NM_001253908.2, NM_001253909.2, NM_003739.6, NM_016253.1
- RefSeq protein
- NP_001240837.1, NP_001240838.1, NP_003730.4
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
aldo-keto reductase family 1 member C3
- Symbol
- AKR1C3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:5,035,354-5,108,244
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein AKR1C3 PDB 1ry0.png
Show 8 more facts
- HomoloGene ID
- 128661
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/8644
- chromosome
- human chromosome 10
- genomic start
- 5077546
- genomic end
- 5149878
- cytogenetic location
- 10p15.1
- Commons category
- Prostaglandin d2 11-ketoreductase (akr1c3)
Sources (3)
via Wikidata · CC0
~2 min read
Encyclopedic overview
7 sectionsContents
- Function
- Pathology
- Isozymes of aldo-keto reductase family 1 member C
- See also
- References
- External links
- Further reading
Aldo-keto reductase family 1 member C3 (AKR1C3), also known as 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5, HSD17B5) or 3α-hydroxysteroid dehydrogenase type 2 (3α-HSD2) is a steroidogenic enzyme that in humans is encoded by the AKR1C3 gene.
== Function == This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin D2, prostaglandin H2, and phenanthrenequinone, and the oxidation of prostaglandin F2α to prostaglandin D2. It is also capable of metabolizing estrogen and progesterone.
Excerpted from Wikipedia’s “AKR1C3” article, available under the CC BY-SA 4.0 licence.