PRKAA2
Sign in to saveAlso known as AMPK, AMPK2, AMPKa2, PRKAA, protein kinase AMP-activated catalytic subunit alpha 2
'''5'-AMP-activated protein kinase catalytic subunit alpha-2' is an enzyme that in humans is encoded by the PRKAA2'' gene.
In the Vinony graph
Within Vinony's link graph, PRKAA2 is referenced by 300 other articles, and connects out to PubMed, human chromosome 1 and Ensembl genome database project.
Vinony files it under EC 2.7.11 and Genes on human chromosome 1.
Its subject is documented across 6 Wikipedia language editions.
Gene data
PRKAA2- Name
- protein kinase AMP-activated catalytic subunit alpha 2
- Type
- protein-coding
- Position
- 56,645,206–56,715,335 (+)
- Aliases
- AMPK, AMPK2, AMPKa2, PRKAA
- Ensembl
- ENSG00000162409
- RefSeq RNA
- NM_006252.4, XM_017001693.2, XM_054337539.1
- RefSeq protein
- NP_006243.2, XP_016857182.1, XP_054193514.1
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
protein kinase AMP-activated catalytic subunit alpha 2
- Symbol
- PRKAA2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:56,645,206-56,715,335
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein PRKAA2 PDB 2h6d.png
Show 7 more facts
- HomoloGene ID
- 4551
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/5563
- genomic end
- 57181008
- genomic start
- 57110995
- chromosome
- human chromosome 1
- cytogenetic location
- 1p32.2
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Function
- References
- Further reading
'''5'-AMP-activated protein kinase catalytic subunit alpha-2' is an enzyme that in humans is encoded by the PRKAA2'' gene.
== Function ==
Excerpted from Wikipedia’s “PRKAA2” article, available under the CC BY-SA 4.0 licence.