AKTIP
Sign in to saveAlso known as FT1, FTS, AKT interacting protein
AKT-interacting protein is a protein that in humans is encoded by the AKTIP gene.
Gene data
AKTIP- Name
- AKT interacting protein
- Type
- protein-coding
- Position
- 53,490,502–53,504,411 (−)
- Aliases
- FT1, FTS
- Ensembl
- ENSG00000166971
- RefSeq RNA
- NM_001012398.3, NM_001308325.2, NM_022476.4, XM_005256095.6, XM_005256096.6
- RefSeq protein
- NP_001012398.1, NP_001295254.1, NP_071921.1, XP_005256152.1, XP_005256153.1
The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
AKT interacting protein
- Symbol
- AKTIP
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 16:53,490,502-53,504,411
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 7721
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/64400
- genomic end
- 53538323
- genomic start
- 53524952
- chromosome
- human chromosome 16
- cytogenetic location
- 16q12.2
- expressed in
- vastus lateralis muscle
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Interactions
- Molecular genetics
- References
- External links
- Further reading
AKT-interacting protein is a protein that in humans is encoded by the AKTIP gene.
The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.
Excerpted from Wikipedia’s “AKTIP” article, available under the CC BY-SA 4.0 licence.