AKTIP

Also known as FT1, FTS, AKT interacting protein

جين من أنواع جينات الإنسان العاقل

In the Vinony graph

Within Vinony's link graph, AKTIP is referenced by 2 other articles, and connects out to PubMed, human chromosome 16 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 16.

Its subject is documented across 5 Wikipedia language editions.

Gene data

AKTIP

Name: AKT interacting protein
Type: protein-coding
Position: 53,490,502–53,504,411 (−)
Aliases: FT1, FTS
Ensembl: ENSG00000166971
RefSeq RNA: NM_001012398.3, NM_001308325.2, NM_022476.4, XM_005256095.6, XM_005256096.6
RefSeq protein: NP_001012398.1, NP_001295254.1, NP_071921.1, XP_005256152.1, XP_005256153.1

The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].