Structure via PubChem · Public domain (PubChem)
alovudine
Sign in to saveAlso known as MIV-310, 3'-Fluoro-3'-deoxythymidine
Alovudine (fluorothymidine) is an antiviral agent which was being developed by Medivir. It was discontinued after a Phase II trial in 2005 due to toxicity. It is a DNA polymerase inhibitor.
Chemical data
- Formula
- C10H13FN2O4
- Molecular weight
- 244.22 g/mol
- IUPAC name
- 1-[(2R,4S,5R)-4-fluoro-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
- SMILES
- CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)F
- InChIKey
- UXCAQJAQSWSNPQ-XLPZGREQSA-N
- XLogP
- -0.3
- Polar surface area
- 78.9 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- HIV infection
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 244.086
Show 4 more facts
- Commons category
- Alovudine
- chemical formula
- C₁₀H₁₃FN₂O₄
- canonical SMILES
- CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)F
- isomeric SMILES
- CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)F
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Alovudine (fluorothymidine) is an antiviral agent which was being developed by Medivir. It was discontinued after a Phase II trial in 2005 due to toxicity. It is a DNA polymerase inhibitor.
== See also == Fluorothymidine F-18, an isotopically enriched version of alovudine used as a PET tracer
Excerpted from Wikipedia’s “alovudine” article, available under the CC BY-SA 4.0 licence.