Structure via PubChem · Public domain (PubChem)
alphamethadol
Sign in to saveAlso known as alpha-methadol
Alphamethadol (INN), or α-methadol, also known as alfametadol, is a synthetic opioid analgesic. It is an isomer of dimepheptanol (methadol), the other being betamethadol (β-methadol). Alphamethadol is composed of two isomers itself, L-α-methadol, and D-α-methadol. Both of alphamethadol's isomers bind to and activate the μ-opioid receptor and are active as opioid analgesics, similarly to those of alphacetylmethadol (α-acetylmethadol).
Chemical data
- Formula
- C21H29NO
- Molecular weight
- 311.5 g/mol
- IUPAC name
- (3R,6R)-6-(dimethylamino)-4,4-diphenylheptan-3-ol
- SMILES
- CC[C@H](C(C[C@@H](C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2)O
- InChIKey
- QIRAYNIFEOXSPW-YLJYHZDGSA-N
- XLogP
- 3.7
- Polar surface area
- 23.5 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- dimepheptanol
- Mass
- 311.225
Show 4 more facts
- chemical formula
- C₂₁H₂₉NO
- canonical SMILES
- CCC(C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2)O
- isomeric SMILES
- CC[C@H](C(C[C@@H](C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2)O
- Commons category
- Alphamethadol
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Legal status
- Australia
- References
Alphamethadol (INN), or α-methadol, also known as alfametadol, is a synthetic opioid analgesic. It is an isomer of dimepheptanol (methadol), the other being betamethadol (β-methadol). Alphamethadol is composed of two isomers itself, L-α-methadol, and D-α-methadol. Both of alphamethadol's isomers bind to and activate the μ-opioid receptor and are active as opioid analgesics, similarly to those of alphacetylmethadol (α-acetylmethadol).
==Legal status==
Excerpted from Wikipedia’s “alphamethadol” article, available under the CC BY-SA 4.0 licence.