AMBN
Sign in to saveAlso known as AI1F, Sheathlin, ameloblastin
Ameloblastin (abbreviated AMBN and also known as sheathlin or amelin) is an enamel matrix protein that in humans is encoded by the AMBN gene.
Gene data
AMBN- Name
- ameloblastin
- Type
- protein-coding
- Aliases
- AI1F
This gene encodes the nonamelogenin enamel matrix protein ameloblastin. The encoded protein may be important in enamel matrix formation and mineralization. This gene is located in the calcium-binding phosphoprotein gene cluster on chromosome 4. Mutations in this gene may be associated with dentinogenesis imperfect and autosomal dominant amylogenesis imperfect. [provided by RefSeq, Aug 2011].
via MyGene.info
Gene · Ensembl
ameloblastin
- Symbol
- AMBN
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 4:70,592,256-70,607,288
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 7625
- exact match
- identifiers.org/ncbigene/258
- genomic end
- 71473005
- genomic start
- 71457973
- cytogenetic location
- 4q13.3
Sources (4)
via Wikidata · CC0
~2 min read
Article
5 sectionsContents
- Function
- Clinical significance
- References
- Further reading
- External links
Ameloblastin (abbreviated AMBN and also known as sheathlin or amelin) is an enamel matrix protein that in humans is encoded by the AMBN gene.
== Function == Ameloblastin is a specific protein found in tooth enamel. Although less than 5% of enamel consists of protein, ameloblastins constitute 5–10% of all enamel protein, making it the second most abundant enamel matrix protein. This protein is formed by ameloblasts during the early secretory to late maturation stages of amelogenesis. Although not completely understood, the function of ameloblastins is believed to be in controlling the elongation of enamel crystals and generally directing enamel mineralization during tooth development. Ameloblastin helps in the growth of a crystalline enameloid layer consisting of randomly oriented short enamel crystals. Ameloblastin cleavage products are found in the sheath space between rod and interrod enamel, while intact ameloblastin accumulates on the enamel rods. This difference in localization is thought to maintain the boundary between rod and interrod enamel.