AMBN

Also known as AI1F, Sheathlin, ameloblastin

Ameloblastin (abbreviated AMBN and also known as sheathlin or amelin) is an enamel matrix protein that in humans is encoded by the AMBN gene.

Gene data

AMBN

Name: ameloblastin
Type: protein-coding
Position: 70,592,256–70,607,288 (+)
Aliases: AI1F
Ensembl: ENSG00000178522
RefSeq RNA: NM_016519.6
RefSeq protein: NP_057603.1

This gene encodes the nonamelogenin enamel matrix protein ameloblastin. The encoded protein may be important in enamel matrix formation and mineralization. This gene is located in the calcium-binding phosphoprotein gene cluster on chromosome 4. Mutations in this gene may be associated with dentinogenesis imperfect and autosomal dominant amylogenesis imperfect. [provided by RefSeq, Aug 2011].

Gene Ontology

Biological process

cell adhesion cell adhesion signal transduction regulation of cell population proliferation odontogenesis of dentin-containing tooth

Molecular function

protein binding growth factor activity growth factor activity structural constituent of tooth enamel

Cellular component

endoplasmic reticulum lumen non-collagenous component of interstitial matrix

Pathways

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)Metabolism of proteins Post-translational protein modification Post-translational protein phosphorylation

via MyGene.info

Gene · Ensembl

ameloblastin

Symbol: AMBN
Biotype: Protein coding
Organism: Homo sapiens
Location: 4:70,592,256-70,607,288
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 9 more facts

HomoloGene ID: 7625
encodes: Ameloblastin
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/258
genomic end: 71473005
genomic start: 71457973
chromosome: human chromosome 4
cytogenetic location: 4q13.3
expressed in: mesencephalon

Sources (4)

via Wikidata · CC0

~2 min read

Encyclopedic overview

5 sections

Contents

Function
Clinical significance
References
Further reading
External links

Ameloblastin (abbreviated AMBN and also known as sheathlin or amelin) is an enamel matrix protein that in humans is encoded by the AMBN gene.

== Function == Ameloblastin is a specific protein found in tooth enamel. Although less than 5% of enamel consists of protein, ameloblastins constitute 5–10% of all enamel protein, making it the second most abundant enamel matrix protein. This protein is formed by ameloblasts during the early secretory to late maturation stages of amelogenesis. Although not completely understood, the function of ameloblastins is believed to be in controlling the elongation of enamel crystals and generally directing enamel mineralization during tooth development. Ameloblastin helps in the growth of a crystalline enameloid layer consisting of randomly oriented short enamel crystals. Ameloblastin cleavage products are found in the sheath space between rod and interrod enamel, while intact ameloblastin accumulates on the enamel rods. This difference in localization is thought to maintain the boundary between rod and interrod enamel.

Excerpted from Wikipedia’s “AMBN” article, available under the CC BY-SA 4.0 licence.