amelogenin
Sign in to saveAlso known as IPR004116
Amelogenins are a group of protein isoforms produced by alternative splicing or proteolysis from the AMELX gene, on the X chromosome, and also the AMELY gene in males, on the Y chromosome. They are involved in amelogenesis, the development of enamel. Amelogenins are type of extracellular matrix protein, which, together with ameloblastins, enamelins and tuftelins, direct the mineralization of enamel to form a highly organized matrix of rods, interrod crystal and proteins.
Key facts
- Protein.Name
- amelogenin, Y-linked
- Protein.HGNCid
- 462
- Protein.Symbol
- AMELY
- Protein.AltSymbols
- AMGL
- Protein.EntrezGene
- 266
- Protein.OMIM
- 410000
- Protein.RefSeq
- NM_001143
- Protein.UniProt
- Q99218
- Protein.Chromosome
- Y
- Protein.Arm
- p
- Protein.Band
- 11
- Protein.LocusSupplementaryData
- -p22.1
via Wikipedia infobox
Research
2,434 papers- Amelogenin-Derived Peptides in Bone Regeneration: A Systematic Review.International journal of molecular sciences · 2021
- The amelogenin gene.The International journal of developmental biology · 1995
- Amelogenin: lessons from evolution.Archives of oral biology · 2005
- Alternatives to amelogenin markers for sex determination in humans and their forensic relevance.Molecular biology reports · 2020
- Epitope mapping of anti-amelogenin IgA in coeliac disease.European journal of oral sciences · 2020
via PubMed
~5 min read
Article
6 sectionsContents
- Function
- Variants
- Application in sex determination
- Clinical significance
- See also
- References
Amelogenins are a group of protein isoforms produced by alternative splicing or proteolysis from the AMELX gene, on the X chromosome, and also the AMELY gene in males, on the Y chromosome. They are involved in amelogenesis, the development of enamel. Amelogenins are type of extracellular matrix protein, which, together with ameloblastins, enamelins and tuftelins, direct the mineralization of enamel to form a highly organized matrix of rods, interrod crystal and proteins.
Although the precise role of amelogenin(s) in regulating the mineralization process is unknown, it is known that amelogenins are abundant during amelogenesis. Developing human enamel contains about 70% protein, 90% of which are amelogenins.