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An anodyne is a drug used to lessen pain through reducing the sensitivity of the brain or nervous system. The term was common in medicine before the 20th century, but such drugs are now more often known as analgesics or painkillers.

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An anodyne is a drug used to lessen pain through reducing the sensitivity of the brain or nervous system. The term was common in medicine before the 20th century, but such drugs are now more often known as analgesics or painkillers.

The term anodyne derives from Greek anōdynos (), from an- (, "without") and odynē (, "pain"). Etymologically, the word covers any substance that reduces pain, but doctors used it more narrowly. Some definitions restrict the term to topical medications, including herbal simples such as onion, lily, root of mallows, leaves of violet, and elderberry. Other definitions include ingested narcotics, hypnotics, and opioids. In the 19th century, the primary anodynes were opium, henbane, hemlock, tobacco, nightshade (stramonium), and chloroform.

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