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Structure via PubChem · Public domain (PubChem)
antalarmin
Sign in to saveAntalarmin (CP-156,181) is a drug that acts as a CRH1 antagonist.
Chemical data
- Formula
- C24H34N4
- Molecular weight
- 378.6 g/mol
- IUPAC name
- N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-amine
- SMILES
- CCCCN(CC)C1=NC(=NC2=C1C(=C(N2C3=C(C=C(C=C3C)C)C)C)C)C
- InChIKey
- IXPROWGEHNVJOY-UHFFFAOYSA-N
- XLogP
- 6.6
- Polar surface area
- 34 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 378.278347
Show 2 more facts
- chemical formula
- C₂₄H₃₄N₄
- canonical SMILES
- CCCCN(CC)C1=NC(=NC2=C1C(=C(N2C3=C(C=C(C=C3C)C)C)C)C)C
Sources (2)
via Wikidata · CC0
~11 min read
Encyclopedic overview
11 sectionsContents
- Chemical structure
- Mechanism of action
- Receptor binding
- Pharmacokinetics (ADME)
- ''In vitro'' and ''in vivo'' research
- Stress and anxiety
- Neurodegeneration
- Inflammation
- Addiction
- See also
- References
Antalarmin (CP-156,181) is a drug that acts as a CRH1 antagonist.
Corticotropin-releasing hormone (CRH), also known as Corticotropin-releasing factor, is an endogenous peptide hormone released in response to various triggers such as chronic stress and drug addiction. Such triggers result in the release of corticotropin (ACTH), another hormone involved in the physiological response to stress. Chronic release of CRH and ACTH is believed to be directly or indirectly involved in many of the harmful physiological effects of chronic stress, such as excessive glucocorticoid release, stomach ulcers, anxiety, diabetes mellitus, osteoporosis, depression, and development of high blood pressure and consequent cardiovascular problems.
Excerpted from Wikipedia’s “antalarmin” article, available under the CC BY-SA 4.0 licence.