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The Antofagasta Region is an administrative division in northern Chile. It matters as a major area of Chile's territory and governance structure.
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The Antofagasta Region (Spanish: Región de Antofagasta, pronounced [antofaˈɣasta]) is one of Chile's sixteen first-order administrative divisions. Being the second-largest region of Chile in area, it comprises three provinces, Antofagasta, El Loa and Tocopilla. It is bordered to the north by Tarapacá, by Atacama to the south, and to the east by Bolivia and Argentina. The region's capital is the port city of Antofagasta; another one of its important cities is Calama. The region's main economic activity is copper mining in its giant inland porphyry copper systems.
Antofagasta's climate is extremely arid, albeit somewhat milder near the coast. Nearly all of the region is devoid of vegetation, except close to the Loa River and at oases such as San Pedro de Atacama. Much of the inland is covered by salt flats, tephra and lava flows, and the coast exhibits prominent cliffs.