aplaviroc
Sign in to saveAlso known as AK-602, GW 873140, GW873140A
Aplaviroc (INN, codenamed AK602 and GSK-873140) is a CCR5 entry inhibitor that belongs to a class of 2,5-diketopiperazines developed for the treatment of HIV infection. It was developed by GlaxoSmithKline.
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 577.315
Show 5 more facts
- chemical formula
- C₃₃H₄₃N₃O₆
- canonical SMILES
- CCCCN1C(=O)C(NC(=O)C12CCN(CC2)CC3=CC=C(C=C3)OC4=CC=C(C=C4)C(=O)O)C(C5CCCCC5)O
- isomeric SMILES
- CCCCN1C(=O)[C@H](NC(=O)C12CCN(CC2)CC3=CC=C(C=C3)OC4=CC=C(C=C4)C(=O)O)[C@@H](C5CCCCC5)O
- physically interacts with
- C-C motif chemokine receptor 5
- Commons category
- Aplaviroc
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Encyclopedic overview
3 sectionsContents
- See also
- References
- Further reading
{{Infobox drug | verifiedrevid = 451871816 | IUPAC_name = 4-(4-{[(3R)-1-butyl-3-[(R)-cyclohexylhydroxymethyl]-2,5-dioxo- 1,4,9-triazaspiro[5.5]undecan-9-yl]methyl}phenoxy)benzoic acid | image = Aplaviroc structure.svg | image_class = skin-invert-image | width = 300
| pregnancy_category = | legal_status = Development terminated | routes_of_administration = Oral
Excerpted from Wikipedia’s “aplaviroc” article, available under the CC BY-SA 4.0 licence.