Apremilast, sold under the brand name Otezla among others, is a medication for the treatment of certain types of psoriasis and psoriatic arthritis. The drug acts as a selective inhibitor of the enzyme phosphodiesterase 4 (PDE4). It is taken by mouth.
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{{Infobox drug | image = Apremilast.svg | image_class = skin-invert-image | width = 215 | alt = | image2 = Apremilast molecule ball.png | image_class2 = bg-transparent | width2 = 215 | alt2 =
| pronounce = | tradename = Otezla, others | Drugs.com = | MedlinePlus = a614022 | DailyMedID = Apremilast | pregnancy_AU = B3 | pregnancy_AU_comment = | pregnancy_category = | routes_of_administration = By mouth | class = | ATC_prefix = L04 | ATC_suffix = AA32 | ATC_supplemental =
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).