methotrexate

Also known as amethopterin, 4-amino-10-methylfolic acid, 4-amino-N(10)-methylpteroylglutamic acid, MTX, N-(4-{[(2,4-diamino-6-pteridinyl)methyl]methylamino}benzoyl)-L-glutamic acid

Methotrexate, formerly known as amethopterin, is a chemotherapy agent and immune-system suppressant. It is used to treat cancer, autoimmune diseases, and ectopic pregnancies. Types of cancers it is used for include breast cancer, leukemia, lung cancer, lymphoma, gestational trophoblastic disease, and osteosarcoma. Types of autoimmune diseases it is used for include psoriasis, rheumatoid arthritis, and Crohn's disease. It can be given by mouth or by injection.

Key facts

Drug.legal_status: Rx-only
Drug.Watchedfields: changed
Drug.verifiedrevid: 464193974
Drug.image: Methotrexate skeletal.svg
Drug.image_class: skin-invert-image
Drug.width: 300
Drug.image2: Methotrexate-from-xtal-3D-bs-17.png
Drug.image_class2: bg-transparent
Drug.width2: 300
Drug.tradename: Trexall, Rheumatrex, Otrexup, others
Drug.MedlinePlus: a682019
Drug.DailyMedID: Methotrexate
Drug.pregnancy_AU

~15 min read

Article

13 sections

Contents

Medical uses
Chemotherapy
Autoimmune disorders
Atopic dermatitis
During pregnancy
Administration
Adverse effects
Drug interactions
Vaccine interactions
Mechanism of action
History
References
External links

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