ARFGEF2
Sign in to saveAlso known as BIG2, PVNH2, dJ1164I10.1, ADP ribosylation factor guanine nucleotide exchange factor 2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2 is a protein that in humans is encoded by the ARFGEF2 gene.
Gene data
ARFGEF2- Name
- ARF guanine nucleotide exchange factor 2
- Type
- protein-coding
- Position
- 48,921,707–49,036,693 (+)
- Aliases
- BIG2, PVNH2, dJ1164I10.1
- Ensembl
- ENSG00000124198
- RefSeq RNA
- NM_001410846.1, NM_006420.3, XM_047439832.1, XM_054322843.1
- RefSeq protein
- NP_001397775.1, NP_006411.2, XP_047295788.1, XP_054178818.1
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
ARF guanine nucleotide exchange factor 2
- Symbol
- ARFGEF2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:48,921,707-49,036,693
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 111880
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/10564
- genomic end
- 47653230
- genomic start
- 48921711
- chromosome
- human chromosome 20
- cytogenetic location
- 20q13.13
- expressed in
- retinal pigment epithelium
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Function
- Interactions
- References
- External links
- Further reading
Brefeldin A-inhibited guanine nucleotide-exchange protein 2 is a protein that in humans is encoded by the ARFGEF2 gene.
== Function ==
Excerpted from Wikipedia’s “ARFGEF2” article, available under the CC BY-SA 4.0 licence.