ARFGEF1
Sign in to saveAlso known as ARFGEP1, BIG1, P200, ADP ribosylation factor guanine nucleotide exchange factor 1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1 is a protein that in humans is encoded by the ARFGEF1 gene.
Gene data
ARFGEF1- Name
- ARF guanine nucleotide exchange factor 1
- Type
- protein-coding
- Aliases
- ARFGEP1, BIG1, DEDISB, P200
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Aug 2011].
via MyGene.info
Gene · Ensembl
ARF guanine nucleotide exchange factor 1
- Symbol
- ARFGEF1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:67,173,511-67,343,961
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 4687
- chromosome
- human chromosome 8
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/10565
- genomic start
- 68085747
- genomic end
- 67343781
- cytogenetic location
- 8q13.2
- expressed in
- tibia
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Function
- Interactions
- References
- External links
- Further reading
Brefeldin A-inhibited guanine nucleotide-exchange protein 1 is a protein that in humans is encoded by the ARFGEF1 gene.
== Function ==
Excerpted from Wikipedia’s “ARFGEF1” article, available under the CC BY-SA 4.0 licence.