ARHGEF10

Also known as GEF10, SNCV, Rho guanine nucleotide exchange factor 10

The human ARHGEF10 gene encodes the protein Rho guanine nucleotide exchange factor 10.

Gene data

ARHGEF10

Name: Rho guanine nucleotide exchange factor 10
Type: protein-coding
Position: 1,823,332–1,958,642 (+)
Aliases: GEF10, SNCV
Ensembl: ENSG00000104728
RefSeq RNA: NM_001308152.2, NM_001308153.3, NM_001438091.1, NM_001438092.1, NM_001438093.1
RefSeq protein: NP_001295081.1, NP_001295082.2, NP_001425020.1, NP_001425021.1, NP_001425022.1

This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].

Pathways

Signal Transduction NRAGE signals death through JNK p75 NTR receptor-mediated signalling Signaling by Rho GTPases Cell death signalling via NRAGE, NRIF and NADE Signaling by GPCR GPCR downstream signalling G alpha (12/13) signalling events Death Receptor Signaling RHOA GTPase cycle

via MyGene.info

Gene · Ensembl

Rho guanine nucleotide exchange factor 10

Symbol: ARHGEF10
Biotype: Protein coding
Organism: Homo sapiens
Location: 8:1,823,332-1,958,642
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

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Encyclopedic overview

3 sections

Contents

References
External links
Further reading

The human ARHGEF10 gene encodes the protein Rho guanine nucleotide exchange factor 10.

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals.

Excerpted from Wikipedia’s “ARHGEF10” article, available under the CC BY-SA 4.0 licence.