ARNT2
Sign in to saveAlso known as WEDAS, bHLHe1, aryl hydrocarbon receptor nuclear translocator 2
gene umano
Gene data
ARNT2- Name
- aryl hydrocarbon receptor nuclear translocator 2
- Type
- protein-coding
- Position
- 80,404,099–80,597,937 (+)
- Aliases
- WEDAS, bHLHe1
- Ensembl
- ENSG00000172379
- RefSeq RNA
- NM_014862.4
- RefSeq protein
- NP_055677.3
This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting additional roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively. [provided by RefSeq, Dec 2013].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
aryl hydrocarbon receptor nuclear translocator 2
- Symbol
- ARNT2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 15:80,404,099-80,597,937
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 7230
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/9915
- genomic end
- 80597933
- genomic start
- 80696692
- chromosome
- human chromosome 15
- cytogenetic location
- 15q25.1
- expressed in
- ventral tegmental area
Sources (4)
via Wikidata · CC0