ARNT2

Also known as WEDAS, bHLHe1, aryl hydrocarbon receptor nuclear translocator 2

Aryl hydrocarbon receptor nuclear translocator 2 is a protein that in humans is encoded by the ARNT2 gene.

In the Vinony graph

Within Vinony's link graph, ARNT2 is referenced by 7 other articles, and connects out to PubMed, human chromosome 15 and Ensembl genome database project.

It sits within the topics Genes on human chromosome 15 and PAS-domain-containing proteins.

Its subject is documented across 5 Wikipedia language editions.

Gene data

ARNT2

Name: aryl hydrocarbon receptor nuclear translocator 2
Type: protein-coding
Position: 80,404,099–80,597,937 (+)
Aliases: WEDAS, bHLHe1
Ensembl: ENSG00000172379
RefSeq RNA: NM_014862.4
RefSeq protein: NP_055677.3

This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting additional roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively. [provided by RefSeq, Dec 2013].

Gene Ontology

Biological process

response to hypoxia response to hypoxia in utero embryonic development in utero embryonic development regulation of DNA-templated transcription regulation of DNA-templated transcription regulation of transcription by RNA polymerase II xenobiotic metabolic process

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity

Cellular component

chromatin nucleus nucleus nucleus nucleoplasm nucleoplasm transcription regulator complex cytoplasm

Pathways

Pathways in cancer - Homo sapiens (human)Transcriptional misregulation in cancer - Homo sapiens (human)Renal cell carcinoma - Homo sapiens (human)Metabolism PPARA activates gene expression Biological oxidations Cytochrome P450 - arranged by substrate type Phase I - Functionalization of compounds Endogenous sterols Xenobiotics

via MyGene.info

Gene · Ensembl

aryl hydrocarbon receptor nuclear translocator 2

Symbol: ARNT2
Biotype: Protein coding
Organism: Homo sapiens
Location: 15:80,404,099-80,597,937
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 7230
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/9915
genomic end: 80597933
genomic start: 80696692
chromosome: human chromosome 15
cytogenetic location: 15q25.1
expressed in: ventral tegmental area

Sources (4)

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Encyclopedic overview

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Further reading

Aryl hydrocarbon receptor nuclear translocator 2 is a protein that in humans is encoded by the ARNT2 gene.

This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively.

Excerpted from Wikipedia’s “ARNT2” article, available under the CC BY-SA 4.0 licence.