Skip to content
Vinony
English
EnglishDeutschEspañolFrançaisItalianoNederlandsPortuguêsSvenskaTürkçe
GeneQ18046601· pop 5· linked from 3 articles

ASRGL1

Sign in to save

Also known as ALP, ALP1, CRASH, asparaginase like 1, asparaginase and isoaspartyl peptidase 1

L-asparaginase is an enzyme that in humans is encoded by the ASRGL1 gene.

Gene data

ASRGL1
Name
asparaginase and isoaspartyl peptidase 1
Type
protein-coding
Position
62,337,347–62,393,415 (+)
Aliases
ALP, ALP1, CRASH
Ensembl
ENSG00000162174
RefSeq RNA
NM_001083926.2, NM_001441216.1, NM_001441217.1, NM_025080.4, XM_011545265.4
RefSeq protein
NP_001077395.1, NP_001428145.1, NP_001428146.1, NP_079356.3, XP_011543567.1

Enables asparaginase activity and beta-aspartyl-peptidase activity. Involved in asparagine catabolic process via L-aspartate. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Pathways

Alanine, aspartate and glutamate metabolism - Homo sapiens (human)MetabolismMetabolism of amino acids and derivativesPhenylalanine and tyrosine metabolismPhenylalanine metabolism

via MyGene.info

Gene · Ensembl

asparaginase and isoaspartyl peptidase 1

Symbol
ASRGL1
Biotype
Protein coding
Organism
Homo sapiens
Location
11:62,337,347-62,393,415
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 9 more facts
HomoloGene ID
11825
chromosome
human chromosome 11
genetic association
chronic obstructive pulmonary disease
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/80150
genomic end
62160882
genomic start
62104920
cytogenetic location
11q12.3
expressed in
cerebellar vermis
Sources (6)

via Wikidata · CC0

~1 min read

Encyclopedic overview

5 sections
Contents
  • Function
  • Clinical significance
  • References
  • External links
  • Further reading

L-asparaginase is an enzyme that in humans is encoded by the ASRGL1 gene.

== Function == The ASRGL1 protein consists of 308 amino acids and is activated by autocleavage at amino acid 168 to form an alpha- and a beta-chain, which can dimerize into a heterodimer. The ASRGL1 enzyme has both L-asparaginase and beta-aspartyl peptidase activity and may be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions.

Excerpted from Wikipedia’s “ASRGL1” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0