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atrolysin A
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Zinc metalloproteinase-disintegrin-like atrolysin-A
- Organism
- Crotalus atrox (Western diamondback rattlesnake)
- Length
- 419 aa
- Molecular mass
- 46,879 Da
- Evidence
- 1: Evidence at protein level
Snake venom zinc metalloproteinase-disintegrin that causes hemorrhage by provoking the degradation of the sub-endothelial matrix proteins (fibronectin, laminin, type IV collagen, nidogen, and gelatins) and disturbances in platelet function. The recombinant cysteine-rich domain interacts with the alpha-2/beta-1 integrin (ITGA2/ITGB1) (collagen receptor), and inhibits the platelet aggregation induced by collagen
CalciumDirect protein sequencingDisulfide bondGlycoproteinHemorrhagic toxinHemostasis impairing toxinHydrolaseMetal-binding
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Swiss-Prot (reviewed) · via UniProt
Wikidata facts
- Instance of
- protein
- Subclass of
- metalloproteinase
Show 3 more facts
- EC enzyme number
- 3.4.24.1
- found in taxon
- western diamondback rattlesnake
Sources (1)
via Wikidata · CC0