metalloproteinase
Sign in to saveAlso known as metallopeptidase, metalloprotease, metalloproteases, metallopeptidases, metalloproteinases
A metalloproteinase, or metalloprotease, is any protease enzyme whose catalytic mechanism involves a metal. An example is ADAM12 which plays a significant role in the fusion of muscle cells during embryo development, in a process known as myogenesis.
Key facts
- Protein family.Symbol
- Peptidase_M50
- Protein family.Name
- Peptidase_M50
- Protein family.image
- PDB_1af0_EBI.jpg
- Protein family.Pfam
- PF02163
- Protein family.Pfam_clan
- CL0126
- Protein family.InterPro
- IPR008915
- Protein family.MEROPS
- M50
- Protein family.OPM family
- 184
- Protein family.OPM protein
- 3b4r
- Protein family.Membranome superfamily
- 317
via Wikipedia infobox
Research
171,919 papers- Key metalloproteinase-mediated pathways in the kidney.Nature reviews. Nephrology · 2021
- Engineering metalloproteinase inhibitors: tissue inhibitors of metalloproteinases or antibodies, that is the question.Current opinion in biotechnology · 2024
- Metalloproteinases and metalloproteinase inhibitors in age-related diseases.Current pharmaceutical design · 2014
- Metalloproteinase expression in monocytes and macrophages and its relationship to atherosclerotic plaque instability.Arteriosclerosis, thrombosis, and vascular biology · 2008
- Metalloproteinase production from macrophages - a perfect storm leading to atherosclerotic plaque rupture and myocardial infarction.Experimental physiology · 2016
via PubMed
Wikidata facts
Show 2 more facts
- Commons category
- Metalloproteases
- EC enzyme number
- 3.4.-.-
Sources (2)
via Wikidata · CC0
~4 min read
Article
4 sectionsContents
- Classification
- See also
- References
- External links
A metalloproteinase, or metalloprotease, is any protease enzyme whose catalytic mechanism involves a metal. An example is ADAM12 which plays a significant role in the fusion of muscle cells during embryo development, in a process known as myogenesis.
Most metalloproteases require zinc, but some use cobalt. The metal ion is coordinated to the protein via three ligands. The ligands coordinating the metal ion can vary with histidine, glutamate, aspartate, lysine, and arginine. The fourth coordination position is taken up by a labile water molecule.