BCL2 apoptosis regulator
Bcl-2, encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins. BCL2 blocks programmed cell death (apoptosis) while other BCL2 family members can either inhibit or induce it. It was the first apoptosis regulator identified in any organism.
Article
17 sectionsContents
- Isoforms
- Function
- Role in disease
- Cancer
- Auto-immune diseases
- Other
- Diagnostic use
- Targeted therapies
- Oblimersen
- ABT-737 and navitoclax (ABT-263)
- Venetoclax (ABT-199)
- Sonrotoclax (BGB-11417)
- Lisaftoclax (APG-2575)
- Interactions
- See also
- References
- External links
Bcl-2, encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins. BCL2 blocks programmed cell death (apoptosis) while other BCL2 family members can either inhibit or induce it. It was the first apoptosis regulator identified in any organism.
Bcl-2 derives its name from B-cell lymphoma 2, as it is the second member of a range of proteins initially described in chromosomal translocations involving chromosomes 14 and 18 in follicular lymphomas. Orthologs (such as Bcl2 in mice) have been identified in numerous mammals for which complete genome data are available.