BCL2 apoptosis regulator

Protein · UniProt

Apoptosis regulator Bcl-2

Gene

BCL2

Organism

Homo sapiens (Human)

Length

239 aa

Molecular mass

26,266 Da

Evidence

1: Evidence at protein level

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells (PubMed:1508712, PubMed:8183370). Regulates cell death by controlling the mitochondrial membrane permeability (PubMed:11368354). Appears to function in a feedback loop system with caspases (PubMed:11368354). Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (PubMed:11368354). Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation con…

• PHASE1/PHASE2COMPLETED
  Vaccination With Peptides From Anti-apoptotic Proteins in Relapsed Multiple MyelomaHerlev Hospital · NCT01272466
• PHASE1RECRUITING
  Inhibiting the Anti-apoptotic Factor, BCL-2, at the Time of ART Initiation to Promote Apoptosis of HIV-infected Cells and Restrict the Seeding of the HIV Reservoir (The INITIATE Study)Thomas Aagaard Rasmussen · NCT07481175
• PHASE1/PHASE2RECRUITING
  Administration of Venetoclax to Promote Apoptosis of HIV-infected Cells and Reduce the Size of the HIV Reservoir Among People Living With HIV on ARTUniversity of Aarhus · NCT05668026

via ClinicalTrials.gov

Wikidata facts

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protein

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