Structure via PubChem · Public domain (PubChem)
venetoclax
Sign in to saveAlso known as Venclexta, ABT-199, 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-(3-nitro-4-{[(oxan-4-yl)methyl]amino}benzene-1-sulfonyl)-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide, GDC-0199
Venetoclax, sold under the brand names Venclexta and Venclyxto, is a medication used to treat adults with chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), or acute myeloid leukemia (AML).
Key facts
- Drug.image
- Venetoclax.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 275
- Drug.image2
- Venetoclax.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Venclexta, Venclyxto
- Drug.MedlinePlus
- a616028
- Drug.DailyMedID
- Venetoclax
- Drug.pregnancy_AU
- C
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- L01
- Drug.ATC_suffix
- XX52
- Drug.legal_AU
- S4
- Drug.legal_CA
- Rx-only
- Drug.legal_UK
- POM
- Drug.legal_US
- Rx-only
- Drug.legal_EU
- Rx-only
- Drug.legal_status
- Rx-only
via Wikipedia infobox
Chemical data
- Formula
- C45H50ClN7O7S
- Molecular weight
- 868.4 g/mol
- IUPAC name
- 4-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]-N-[3-nitro-4-(oxan-4-ylmethylamino)phenyl]sulfonyl-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide
- SMILES
- CC1(CCC(=C(C1)C2=CC=C(C=C2)Cl)CN3CCN(CC3)C4=CC(=C(C=C4)C(=O)NS(=O)(=O)C5=CC(=C(C=C5)NCC6CCOCC6)[N+](=O)[O-])OC7=CN=C8C(=C7)C=CN8)C
- InChIKey
- LQBVNQSMGBZMKD-UHFFFAOYSA-N
- XLogP
- 8.2
- Polar surface area
- 183 Ų
- H-bond donors
- 3
- H-bond acceptors
- 11
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2016
- Admin. routes
- oral
- Indications
- chronic lymphocytic leukemia, multiple myeloma, non-Hodgkins lymphoma, neoplasm
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 867.318096
Show 6 more facts
- medical condition treated
- chronic lymphocytic leukemia
- chemical formula
- C₄₅H₅₀ClN₇O₇S
- canonical SMILES
- CC1(CCC(=C(C1)C2=CC=C(C=C2)Cl)CN3CCN(CC3)C4=CC(=C(C=C4)C(=O)NS(=O)(=O)C5=CC(=C(C=C5)NCC6CCOCC6)[N+](=O)[O-])OC7=CN=C8C(=C7)C=CN8)C
- subject has role
- antineoplastic
- Commons category
- Venetoclax
- physically interacts with
- BCL2 apoptosis regulator
Sources (9)
via Wikidata · CC0
~14 min read
Encyclopedic overview
12 sectionsContents
- Medical uses
- CLL/SLL
- Other types of leukemia
- Acute myeloid leukemia
- Side effects
- Pharmacology
- Mechanism of action
- Pharmacokinetics
- History
- Society and culture
- Research
- References
{{Infobox drug | image = Venetoclax.svg | image_class = skin-invert-image | width = 275 | alt = | image2 = Venetoclax.png | image_class2 = bg-transparent | alt2 = | caption =
| pronounce = | tradename = Venclexta, Venclyxto | Drugs.com = | MedlinePlus = a616028 | DailyMedID = Venetoclax | pregnancy_AU = C | pregnancy_AU_comment = | pregnancy_category = | routes_of_administration = By mouth | class = | ATC_prefix = L01 | ATC_suffix = XX52 | ATC_supplemental =
Excerpted from Wikipedia’s “venetoclax” article, available under the CC BY-SA 4.0 licence.