Structure via PubChem · Public domain (PubChem)
bexlosteride
Sign in to saveBexlosteride is a potent and noncompetitive inhibitor of the enzyme 5α-reductase related to finasteride and dutasteride. It is selective for the type I isoform of the enzyme. It advanced to Phase III clinical trials, but development was halted at that stage, and it was never marketed.
Chemical data
- Formula
- C14H16ClNO
- Molecular weight
- 249.73 g/mol
- IUPAC name
- (4aR,10bR)-8-chloro-4-methyl-1,2,4a,5,6,10b-hexahydrobenzo[f]quinolin-3-one
- SMILES
- CN1[C@@H]2CCC3=C([C@H]2CCC1=O)C=CC(=C3)Cl
- InChIKey
- WQBIOEFDDDEARX-CHWSQXEVSA-N
- XLogP
- 2.6
- Polar surface area
- 20.3 Ų
- H-bond donors
- 0
- H-bond acceptors
- 1
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 249.092
Show 4 more facts
- chemical formula
- C₁₄H₁₆ClNO
- isomeric SMILES
- CN1[C@@H]2CCC3=C([C@H]2CCC1=O)C=CC(=C3)Cl
- canonical SMILES
- CN1C2CCC3=C(C2CCC1=O)C=CC(=C3)Cl
- Commons category
- Bexlosteride
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
3 sectionsContents
- Synthesis
- See also
- References
Bexlosteride is a potent and noncompetitive inhibitor of the enzyme 5α-reductase related to finasteride and dutasteride. It is selective for the type I isoform of the enzyme. It advanced to Phase III clinical trials, but development was halted at that stage, and it was never marketed.
==Synthesis== The synthesis of Bexlosteride has been reported in the literature.
Excerpted from Wikipedia’s “bexlosteride” article, available under the CC BY-SA 4.0 licence.