Structure via PubChem · Public domain (PubChem)
biricodar
Sign in to saveBiricodar (INN, codename VX-710, brand name Incel) was a pharmaceutical drug under development by Vertex Pharmaceuticals to help treat antineoplastic resistance in cancer.
Chemical data
- Formula
- C34H41N3O7
- Molecular weight
- 603.7 g/mol
- IUPAC name
- 1,7-dipyridin-3-ylheptan-4-yl (2S)-1-[2-oxo-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxylate
- SMILES
- COC1=CC(=CC(=C1OC)OC)C(=O)C(=O)N2CCCC[C@H]2C(=O)OC(CCCC3=CN=CC=C3)CCCC4=CN=CC=C4
- InChIKey
- CGVWPQOFHSAKRR-NDEPHWFRSA-N
- XLogP
- 5.2
- Polar surface area
- 117 Ų
- H-bond donors
- 0
- H-bond acceptors
- 9
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 603.294
Show 3 more facts
- chemical formula
- C₃₄H₄₁N₃O₇
- canonical SMILES
- COC1=CC(=CC(=C1OC)OC)C(=O)C(=O)N2CCCCC2C(=O)OC(CCCC3=CN=CC=C3)CCCC4=CN=CC=C4
- isomeric SMILES
- COC1=CC(=CC(=C1OC)OC)C(=O)C(=O)N2CCCC[C@H]2C(=O)OC(CCCC3=CN=CC=C3)CCCC4=CN=CC=C4
via Wikidata · CC0
~2 min read
Encyclopedic overview
5 sectionsContents
- History
- Synthesis
- Mechanism
- References
- Further reading
Biricodar (INN, codename VX-710, brand name Incel) was a pharmaceutical drug under development by Vertex Pharmaceuticals to help treat antineoplastic resistance in cancer.
Biricodar is considered a second-generation ABC transporter inhibitor and has been described as one of the most famous foundational drugs of this class. Although it has not been brought to market, biricodar continues to be used in basic research and is a compound of interest for potential clinical applications.
Excerpted from Wikipedia’s “biricodar” article, available under the CC BY-SA 4.0 licence.