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GeneQ17854024· pop 5· linked from 3 articles

C1QA

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Also known as complement C1q A chain

Complement C1q subcomponent subunit A is a protein that in humans is encoded by the C1QA gene.

Gene data

C1QA
Name
complement C1q A chain
Type
protein-coding
Position
22,635,057–22,640,201 (+)
Aliases
C1QD1
Ensembl
ENSG00000173372
RefSeq RNA
NM_001347465.2, NM_001347466.2, NM_015991.4
RefSeq protein
NP_001334394.1, NP_001334395.1, NP_057075.1

This gene encodes the A-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum complement system. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016].

Gene Ontology

Pathways

Complement and coagulation cascades - Homo sapiens (human)Prion disease - Homo sapiens (human)Pertussis - Homo sapiens (human)Chagas disease - Homo sapiens (human)Staphylococcus aureus infection - Homo sapiens (human)Coronavirus disease - COVID-19 - Homo sapiens (human)Systemic lupus erythematosus - Homo sapiens (human)DiseaseComplement cascadeInitial triggering of complement

via MyGene.info

Gene · Ensembl

complement C1q A chain

Symbol
C1QA
Biotype
Protein coding
Organism
Homo sapiens
Location
1:22,635,057-22,640,201
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~1 min read

Encyclopedic overview

3 sections
Contents
  • References
  • Further reading
  • External links

Complement C1q subcomponent subunit A is a protein that in humans is encoded by the C1QA gene.

This gene encodes a major constituent of the human complement system subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the A-chain polypeptide of human complement subcomponent C1q.

Excerpted from Wikipedia’s “C1QA” article, available under the CC BY-SA 4.0 licence.

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