File:Human_calcitonin_bound_to_receptor_PDB_7TYO.png · Wikimedia Commons · See Wikimedia Commons
calcitonin
Sign in to saveAlso known as CGRP-I, KC, alpha-type CGRP, CT, CALC1, CALCA, CGRP, calcitonin 1
Calcitonin is a 32 amino acid peptide hormone secreted by parafollicular cells (also known as C cells) of the thyroid (or endostyle) in humans and other chordates in the ultimopharyngeal body. It acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH).
OverviewAI-generated
Calcitonin is a chemical compound with the formula C₁₅₁H₂₂₈N₄₀O₄₅S₃. It has a mass of 3418.597793 and a weight of 3419.9. The molecule carries a charge of 0 and possesses an xlogp value of -11.9. Its topological polar surface area is 1390, with 47 hydrogen bond donors and 51 hydrogen bond acceptors. The MCN code for this substance is 3004.39.25.
In clinical research, calcitonin is associated with 89 entries in the ClinicalTrials.gov database. The subject is referenced by 382 other encyclopedia articles.
Synthesized by Vinony from 16 facts across 4 sources: Wikidata, PubChem, ClinicalTrials.gov, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.
Chemical data
- Formula
- C151H228N40O45S3
- Molecular weight
- 3419.9 g/mol
- IUPAC name
- (3S)-4-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[(2S)-2-[[(2S)-5-amino-1-[[(2S,3R)-1-[[(2S)-1-[[(2S,3S)-1-[[2-[[(2S)-1-[[2-[[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxohexan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-[[(2S)-5-amino-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[2-[[(2R)-2-amino-3-sulfanylpropanoyl]amino]acetyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxybutanoyl]amino]-5-oxopentanoyl]amino]-4-oxobutanoic acid
- SMILES
- CC[C@H](C)[C@@H](C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N)NC(=O)[C@H](C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC4=CN=CN4)NC(=O)[C@H](CC5=CC=CC=C5)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC6=CC=CC=C6)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC7=CC=C(C=C7)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)N)NC(=O)CNC(=O)[C@H](CS)N
- InChIKey
- MKPOFZGVVSUXKS-JKQNMTHDSA-N
- XLogP
- -11.9
- Polar surface area
- 1390 Ų
- H-bond donors
- 47
- H-bond acceptors
- 51
- Formal charge
- 0
via PubChem
Clinical Trials
89 registered- PHASE4RECRUITINGCalcitonin Pre-treatment to Improve SPECT-CT SensitivityJoseph Sferra · NCT03935984
- NACOMPLETEDNasal Calcitonin in the Treatment of Bone Mineral Loss in Children and Adolescents With Inflammatory Bowel DiseaseBoston Children's Hospital · NCT00114803
- PHASE2TERMINATEDEffects of Oral Salmon Calcitonin in Human OsteoarthritisUniversité Catholique de Louvain · NCT00376311
- PHASE4COMPLETEDEfficacy and Safety Study of Rimegepant in Episodic Migraine Prevention With Multiple Dosing RegimensPfizer · NCT05217927
- NARECRUITINGInduction of Migraine Attacks With Aura Using Calcitonin Gene-Related PeptideDanish Headache Center · NCT07021859
- UNKNOWNAnti-CGRP Monoclonal Antibody Response After Switching (AMARAS)Hospital Clínico Universitario de Valladolid · NCT05785988
~12 min read
Encyclopedic overview
19 sectionsContents
- Biosynthesis and regulation
- Function
- Receptor
- Discovery
- Clinical significance
- Pharmacology
- General characteristics of the active substance
- Characteristics in patients
- Preclinical safety data
- Pharmaceutical manufacture
- Uses of calcitonin
- Treatments
- Diagnostics
- Structure
- Research
- See also
- References
- Further reading
- External links
Calcitonin is a 32 amino acid peptide hormone secreted by parafollicular cells (also known as C cells) of the thyroid (or endostyle) in humans and other chordates in the ultimopharyngeal body. It acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH).
Its importance in humans has not been as well established as its importance in other animals, as its function is usually not significant in the regulation of normal calcium homeostasis. It belongs to the calcitonin-like protein family.
Excerpted from Wikipedia’s “calcitonin” article, available under the CC BY-SA 4.0 licence.