alpha fetoprotein
Sign in to saveAlso known as AFP, alpha-1-fetoprotein, alpha-fetoprotein, alpha-fetoglobulin, alpha-Fetoproteins
Alpha-fetoprotein (AFP, α-fetoprotein; also sometimes called alpha-1-fetoprotein, alpha-fetoglobulin, or alpha fetal protein) is a protein that in humans is encoded by the AFP gene. The AFP gene is located on the q arm of chromosome 4 (4q13.3). Maternal AFP serum level is used to screen for Down syndrome, neural tube defects, and other chromosomal abnormalities.
Protein · UniProt
Alpha-fetoprotein
- Gene
- AFP
- Organism
- Homo sapiens (Human)
- Length
- 609 aa
- Molecular mass
- 68,678 Da
- Evidence
- 1: Evidence at protein level
Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties
Swiss-Prot (reviewed) · via UniProt
Research
29,742 papers- Alpha-fetoprotein: Past, present, and future.Hepatology communications · 2024
- Alpha-fetoprotein is an autoantigen in hepatocellular carcinoma and juvenile Batten disease.Frontiers in bioscience (Landmark edition) · 2020
- Effects of alpha-fetoprotein on the occurrence and progression of hepatocellular carcinoma.Journal of cancer research and clinical oncology · 2020
- The Landscape Of Alpha Fetoprotein In Hepatocellular Carcinoma: Where Are We?International journal of biological sciences · 2022
- α-fetoprotein-binding toxins and teratogens against cancer.Therapeutic delivery · 2019
via PubMed
Clinical Trials
66 registered- COMPLETEDAssociation Between Inflammatory Biomarkers in CVD Patients on Empagliflozin.Damanhour University · NCT05911724
- NACOMPLETEDMetformin and Pioglitazone Effects on Fetuin-A and Osteoprotegrin Concentrations in Type 2 Diabetes PatientsTehran University of Medical Sciences · NCT02027103
- COMPLETEDModeling Cancer-specific Prognosis in Liver Transplantation for Hepatocellular Carcinoma (HCC)Fondazione IRCCS Istituto Nazionale dei Tumori, Milano · NCT02898415
- UNKNOWNInvestigation of Human Alpha-fetoprotein GenesNational Taiwan University Hospital · NCT01258894
- NACOMPLETEDFetuin-A Phosphorylation Status in Insulin Resistance and Metabolic SyndromeAuburn University · NCT03478046
- NARECRUITINGBiannual Screening for HCC Offered to Patients With Cirrhosis. Introducing Surveillance for Hepatocellular Carcinoma (HCC) in the Central Denmark Region Using Ultrasound and Alpha-Fetoprotein to Reduce HCC-Related Mortality in Patients With Compensated Non-Viral CirrhosisUniversity of Aarhus · NCT07469319
Wikidata facts
- Mass
- 68678
- Image
- AFP prot.png
Show 1 more fact
- exact match
- purl.uniprot.org/uniprot/P02771
via Wikidata · CC0
~6 min read
Article
10 sectionsContents
- Structure
- Function
- Serum levels
- Maternal
- Infants
- Clinical significance
- See also
- References
- Further reading
- External links
Alpha-fetoprotein (AFP, α-fetoprotein; also sometimes called alpha-1-fetoprotein, alpha-fetoglobulin, or alpha fetal protein) is a protein that in humans is encoded by the AFP gene. The AFP gene is located on the q arm of chromosome 4 (4q13.3). Maternal AFP serum level is used to screen for Down syndrome, neural tube defects, and other chromosomal abnormalities.
AFP is a major plasma protein produced by the yolk sac and the fetal liver during fetal development. It is thought to be the fetal analog of serum albumin. AFP binds to copper, nickel, fatty acids and bilirubin and is found in monomeric, dimeric and trimeric forms.