CCNDBP1
Sign in to saveAlso known as DIP1, GCIP, HHM, cyclin D1 binding protein 1
Cyclin-D1-binding protein 1 is a protein that in humans is encoded by the CCNDBP1 gene.
Gene data
CCNDBP1- Name
- cyclin D1 binding protein 1
- Type
- protein-coding
- Position
- 43,185,118–43,197,177 (+)
- Aliases
- DIP1, GCIP, HHM
- Ensembl
- ENSG00000166946
- RefSeq RNA
- NM_012142.5, NM_037370.2, NR_027513.3, NR_027514.3, NR_045998.2
- RefSeq protein
- NP_036274.3, XP_047288284.1, XP_054233624.1
This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene. [provided by RefSeq, Apr 2009].
Gene Ontology
Molecular function
Cellular component
via MyGene.info
Gene · Ensembl
cyclin D1 binding protein 1
- Symbol
- CCNDBP1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 15:43,185,118-43,197,177
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
4 sectionsContents
- Interactions
- References
- Further reading
- External links
Cyclin-D1-binding protein 1 is a protein that in humans is encoded by the CCNDBP1 gene.
This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Two alternatively spliced variants, which encode distinct isoforms, have been reported.
Excerpted from Wikipedia’s “CCNDBP1” article, available under the CC BY-SA 4.0 licence.