CCND1

Also known as BCL1, D11S287E, PRAD1, U21B31, cyclin D1

protein-coding gene in the species Homo sapiens

Gene data

CCND1

Name: cyclin D1
Type: protein-coding
Position: 69,641,143–69,654,474 (+)
Aliases: BCL1, D11S287E, PRAD1, U21B31
Ensembl: ENSG00000110092
RefSeq RNA: NM_053056.3
RefSeq protein: NP_444284.1

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers. [provided by RefSeq, Dec 2019].