CCNT2

Also known as CYCT2, cyclin T2

gen de la especie Homo sapiens

Gene data

CCNT2

Name: cyclin T2
Type: protein-coding
Position: 134,918,235–134,999,446 (+)
Aliases: CYCT2
Ensembl: ENSG00000082258
RefSeq RNA: NM_001241.4, NM_001320748.2, NM_001320749.2, NM_058241.3, NR_037649.2
RefSeq protein: NP_001232.1, NP_001307677.1, NP_001307678.1, NP_490595.1, XP_016860716.1

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010].

Gene Ontology

Biological process

regulation of cyclin-dependent protein serine/threonine kinase activity regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription by RNA polymerase II skeletal muscle tissue development early viral transcription late viral transcription positive regulation of DNA-templated transcription, elongation

Molecular function

transcription coactivator binding chromatin binding chromatin binding protein binding cyclin-dependent protein serine/threonine kinase regulator activity protein kinase binding cyclin-dependent protein serine/threonine kinase activator activity RNA polymerase binding

Cellular component

nucleus nucleus nucleus nucleus nucleoplasm cyclin/CDK positive transcription elongation factor complex cyclin/CDK positive transcription elongation factor complex cyclin/CDK positive transcription elongation factor complex

Pathways

Transcriptional misregulation in cancer - Homo sapiens (human)Formation of RNA Pol II elongation complex Adaptive Immune System Signal Transduction HIV Life Cycle Late Phase of HIV Life Cycle HIV Infection Disease Formation of HIV elongation complex in the absence of HIV Tat Transcription of the HIV genome

via MyGene.info

Gene · Ensembl

cyclin T2

Symbol: CCNT2
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:134,918,235-134,999,446
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein CCNT2 PDB 2ivx.png

Show 8 more facts

HomoloGene ID: 14043
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/905
genomic start: 135675805
chromosome: human chromosome 2
genomic end: 135716912
cytogenetic location: 2q21.3
expressed in: endometrium

Sources (3)

via Wikidata · CC0

Article · Español

La ciclina T2 (CCNT2) es una proteína codificada en humanos por el gen CCNT2. La ciclina T2 pertenece a la familia de las ciclinas, cuyos miembros se caracterizan por variar drásticamente sus concentraciones a medida que progresa el ciclo celular. Las ciclinas funcionan como reguladores de las quinasas dependientes de ciclinas (Cdks). Las diferentes ciclinas presentan diversos patrones de expresión y degradación que contribuyen a una coordinación temporal de cada fase del ciclo celular. La ciclina T2 y su quinasa correspondiente, Cdk9, son subunidades del factor transcripcional de elongación . El complejo p-TEFb que contiene esta ciclina interacciona y actúa como regulador negativo de la proteína Tat del virus de inmunodeficiencia humana tipo 1 (VIH-1). Se han descrito dos variantes transcripcionales de este gen, que codifican diferentes isoformas de la proteína.

Abstract from DBpedia / Wikipedia · CC BY-SA

Available in 6 languages

via Wikidata sitelinks · CC0

What links here6 pages

CDK9

Gene

RB transcriptional corepressor 1