chlorotoxin
Sign in to saveChlorotoxin is a 36-amino acid peptide found in the venom of the deathstalker scorpion (Leiurus quinquestriatus) which blocks small-conductance chloride channels. The fact that chlorotoxin binds preferentially to glioma cells has allowed the development of methods for the treatment and diagnosis of several types of cancer.
Research
229 papers- Chlorotoxin:Cy5.5.2004
- Chlorotoxin-A Multimodal Imaging Platform for Targeting Glioma Tumors.Toxins · 2018
- Chlorotoxin-directed CAR T cell therapy for recurrent glioblastoma: Interim clinical experience demonstrating feasibility and safety.Cell reports. Medicine · 2025
- (131)I-Chlorotoxin.2004
- Chlorotoxin: a helpful natural scorpion peptide to diagnose glioma and fight tumor invasion.Toxins · 2015
via PubMed
Wikidata facts
Show 1 more fact
- chemical formula
- C₁₅₈H₂₄₉N₅₃O₄₇S₁₁
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Article
7 sectionsContents
- Sources
- Chemistry
- Target
- Toxicity
- Possible therapeutic use
- In popular culture
- References
Chlorotoxin is a 36-amino acid peptide found in the venom of the deathstalker scorpion (Leiurus quinquestriatus) which blocks small-conductance chloride channels. The fact that chlorotoxin binds preferentially to glioma cells has allowed the development of methods for the treatment and diagnosis of several types of cancer.
== Sources ==
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infrared radiation
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House M.D.
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peptide
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Q180686
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L-Cysteine
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Q229883
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ligand
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venom
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